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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
031534-APC.200 | 200 µl | - | - |
3 - 19 business days* |
993.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices... more
Product information "Anti-ACER1, CT (ACER1, ASAH3, Alkaline ceramidase 1, Acylsphingosine deacylase 3, N-acylsphingosine"
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]). Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: | Anti-ASAH3, Anti-ACER1, Anti-AlkCDase 1, EC=3.5.1.23, Anti-Alkaline CDase 1, Anti-Alkaline ceramidase 1, Anti-Acylsphingosine deacylase 3, Anti-N-acylsphingosine amidohydrolase 3 |
Supplier: | United States Biological |
Supplier-Nr: | 031534-APC |
Properties
Application: | FLISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | APC |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the C-terminal region of human ACER1. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K01441 | Matching products |
UniProt ID : | Q8TDN7 | Matching products |
Gene ID | GeneID 125981 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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