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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB9135.50 | 50 µl | - | - |
9 - 20 business days* |
352.00€
|
||
G-CAB9135.100 | 100 µl | - |
9 - 20 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Cotranslational quality control factor involved in the No-Go Decay (NGD)... more
Product information "Anti-ABCE1"
Protein function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132). Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs, this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage, this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:9660177, PubMed:9847332, PubMed:11585831). [The UniProt Consortium]
Keywords: | Anti-RLI, Anti-ABCE1, Anti-RNS4I, Anti-HuHP68, Anti-RNase L inhibitor, Anti-Ribonuclease 4 inhibitor, Anti-2'-5'-oligoadenylate-binding protein, Anti-ATP-binding cassette sub-family E member 1, ABCE1 Rabbit mAb |
Supplier: | Assay Genie |
Supplier-Nr: | CAB9135 |
Properties
Application: | WB, IF |
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Database Information
KEGG ID : | K06174 | Matching products |
UniProt ID : | P61221 | Matching products |
Gene ID | GeneID 6059 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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