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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8183-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V8183-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The two members of the large... more
Product information "Anti-ABCC3 / MRP3, clone ABCC3/2971"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps exp- ressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also medi- ates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. Protein function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. [The UniProt Consortium]
Keywords: | Anti-ABCC3, Anti-MOAT-D, Anti-CMOAT2, Anti-Multidrug resistance-associated protein 3, Anti-Multi-specific organic anion transporter D, Anti-ATP-binding cassette sub-family C member 3, Anti-Canalicular multispecific organic anion transporter 2, ABCC3 Antib |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8183 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | ABCC3/2971 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant human protein fragment (amino acids 815-957) |
Format: | Purified |
Database Information
KEGG ID : | K05667 | Matching products |
UniProt ID : | O15438 | Matching products |
Gene ID | GeneID 8714 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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