Anti-AAK1, Internal

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG65033.100	100 µg		-	-	6 - 14 business days*		784.00€

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Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2... more

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Product information "Anti-AAK1, Internal"

Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. [The UniProt Consortium]

Keywords:	Anti-AAK1, Anti-KIAA1048, EC=2.7.11.1, Anti-Adaptor-associated kinase 1, Anti-AP2-associated protein kinase 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG65033

Properties

Application:	ELISA, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Goat
Species reactivity:	human (Expected: mouse, rat, bovine)
Immunogen:	C-GSPRTSQQNVYNPSE
Format:	Ammonium Sulfate Precipitated