Anti-AAK1

Anti-AAK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-146A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-146A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-146A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2... more
Product information "Anti-AAK1"
Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. [The UniProt Consortium]
Keywords: Anti-AAK1, Anti-KIAA1048, EC=2.7.11.1, Anti-Adaptor-associated kinase 1, Anti-AP2-associated protein kinase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-146A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, Bovine, Pig)
Immunogen: synthetic peptide. The epitope recognized by A302-146A-T maps to a region between residue 350 and 410 of human AP2 associated kinase 1 using the numbering given in entry AAI11966.1 (GeneID 22848).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-AAK1"
Write a review
or to review a product.
Viewed