Anti-Aak1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-X54 100 µg - -

6 - 10 business days*

684.00€
 
Anti-Aak1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-Aak1"
Anti-Aak1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Aak1 from other sources has not been determined. Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. [The UniProt Consortium]
Keywords: Anti-AAK1, Anti-KIAA1048, EC=2.7.11.1, Anti-Adaptor-associated kinase 1, Anti-AP2-associated protein kinase 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-X54

Properties

Application: ELISA, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 20 amino acid synthetic peptide near the N-terminus of the human Aak1.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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