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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-PACO48618.50 | 50 µg | - |
9 - 20 business days* |
363.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
AAK1 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse... more
Product information "Anti-AAK1"
AAK1 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse and for use in ELISA, WB, IHC, IF applications. AAK1 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). [The UniProt Consortium]
Keywords: | Anti-AAK1, Anti-KIAA1048, Anti-Adaptor-associated kinase 1, Anti-AP2-associated protein kinase 1 |
Supplier: | Assay Genie |
Supplier-Nr: | PACO48618 |
Properties
Application: | ELISA, WB, IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant Human AP2-associated protein kinase 1 protein (274-465AA) |
Database Information
KEGG ID : | K08853 | Matching products |
UniProt ID : | Q2M2I8 | Matching products |
Gene ID | GeneID 22848 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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