Anti-a1-Antichymotrypsin (Alpha-1-Antichymotrypsin, AACT, ACT, Growth Inhibiting Protein 24, GIG24,

a1-Antichymotrypsin (AACT, Alpha1-ACT) is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. a1-Antichymotrypsin, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal-aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to a1-Antichymotrypsin. A higher proportion of serum PSA is complexed to a1-Antichymotrypsin in prostate cancer than in benign prostate hyperplasia. Applications: Suitable for use in ELISA, Immunoprecipitation, Immunodiffusion, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.