Obesity represents one of the greatest global health problems. With the addition of the diabetes drug semaglutide, a pharmacological therapy option could now be used to effectively reduce weight.
For the detection of neutralizing antibodies of SARS-CoV-2, sELISA kits offer a convenient alternative to neutralization tests, as they can be used under standard laboratory safety conditions. A recent study compared two commercially available kits and tested their specificity and selectivity.
The B cell-stimulating molecules BAFF and APRIL are critical factors in the maintenance of the B cell pool and humoral immunity.
Progranulin is a stress-induced protein with multifunctional biological activities, including major roles in cancer, inflammation, metabolic diseases and neurodegeneration.
Pyroptosis is an inflammatory programmed cell death, which is induced by inflammatory caspases. During this process, Gasdermin D (GSDMD) is a central mediator of pyroptotic cell death.
Currently, there are no approved drugs to treat the SARS-CoV-2 infection that causes COVID-19. Existing drugs are being examined for strategies to treat the disease.
The novel coronavirus SARS-CoV-2, which causes COVID-19, shares 79.5% sequence identity with the virus responsible for SARS. Both viruses use the same receptor ACE2 for mediating viral entry into host cells.
This article focuses on the differences between white, brown and beige adipose tissue, as well as the role of adipokines in the development of obesity and insulin resistance.