Bortezomib

Bortezomib
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10008822-1 1 mg -

1 - 10 business days

32.00€
Cay10008822-5 5 mg -

1 - 10 business days

70.00€
Cay10008822-10 10 mg -

1 - 10 business days

125.00€
Cay10008822-25 25 mg -

1 - 10 business days

274.00€
 
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki... more
Product information "Bortezomib"
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of cancer. Proteasome inhibitors, including bortezomib, have potential in combination therapy with chemotherapy and radiation therapy against cancer.
Keywords: LDP-341, MG-341, MLN341, NSC 681239, PS-341, Velcade, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid
Supplier: Cayman Chemical
Supplier-Nr: 10008822-1

Properties

Application: Proteasome subunit beta type-1/5 inhibitor
MW: 384.2 D
Formula: C19H25BN4O4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 179324-69-7| Search using CAS
KEGG ID : K02732 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H315, H319, H361, H372, H411
P Phrases: P201, P202, P260, P264, P270, P273, P280, P314, P321, P330, P391, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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