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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay28192-250 | 250 µg | - |
6 - 10 business days* |
369.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Histone H4R3Me2s (1-21)-GGK-biotin is a peptide fragment of histone H4 that corresponds to amino... more
Product information "Histone H4R3Me2s (1-21)-GGK-biotin (trifluoroacetate salt)"
Histone H4R3Me2s (1-21)-GGK-biotin is a peptide fragment of histone H4 that corresponds to amino acid residues 2-22 of the human H4 sequence. It is symmetrically dimethylated at arginine 3 and biotinylated via a C-terminal GGK linker. Symmetric dimethylation of histone 4 at arginine 3 is associated with transcriptional repression. It can recruit the DNA methyltransferase DNMT3a, leading to DNA methylation and further transcriptional repression. Histone H4R3Me2s (1-21)-GGK-biotin has been used as a substrate for the qualitative measurement of jumonji domain containing 1B (JMJD1B) arginine demethylase activity and in dot blot assays to verify antibody specificity.Formal Name: N2-(N2-acetyl-L-serylglycyl-Nomega,Nomega'-dimethyl-L-arginylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-lysyl-L-valylglycylglycyl)-N6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-lysine, trifluoroacetate salt. Synonyms: Ac-SG-R(me2s)-GKGGKGLGKGGAKRHRKV-GGK(Biotin), [Arg(Me2s)3]-Histone H4 (1-21)-GGK(Biotin), Histone H4 (1-21) (Arg3me2s). Molecular Formula: C111H197N43O29S . XCF3COOH. Formula Weight: 2630.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: [H]N(C(C)=O)[C@@H](CO)C(NCC(N[C@@H](CCCNC(N(C)C)=N)C(NCC(N[C@@H](CCCCN)C(NCC(NCC(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(NCC(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](CCCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C111H197N43O29S.C2HF3O2/c1-62(2)46-76(145-91(167)58-133-97(171)69(28-13-19-39-114)140-86(162)53-128-83(159)50-131-95(169)67(26-11-17-37-112)141-88(164)55-132-98(172)70(32-25-45-126-110(121)154(7)8)143-90(166)57-135-100(174)78(59-155)139-65(6)156)99(173)134-56-89(165)142-68(27-12-18-38-113)96(170)130-49-82(158)127-52-85(161)138-64(5)94(168)146-71(29-14-20-40-115)101(175)148-74(34-24-44-125-109(119)120)103(177)150-77(47-66-48-122-61-137-66)105(179)149-73(33-23-43-124-108(117)118)102(176)147-72(30-15-21-41-116)104(178)152-92(63(3)4)106(180)136-51-84(160)129-54-87(163)144-75(107(181)182)31-16-22-42-123-81(157)36-10-9-35-80-93-79(60-184-80)151-111(183)153-93,3-2(4,5)1(6)7/h48,61-64,67-80,92-93,155H,9-47,49-60,112-116H2,1-8H3,(H2,121,126)(H,122,137)(H,123,157)(H,127,158)(H,128,159)(H,129,160)(H,130,170)(H,131,169)(H,132,172)(H,133,171)(H,134,173)(H,135,174)(H,136,180)(H,138,161)(H,139,156)(H,140,162)(H,141,164)(H,142,165)(H,143,166)(H,144,163)(H,145,167)(H,146,168)(H,147,176)(H,148,175)(H,149,179)(H,150,177)(H,152,178)(H,181,182)(H4,117,118,124)(H4,119,120,125)(H2,151,153,183),(H,6,7)/t64-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,92-,93-,/m0./s1. InChi Key: GWMACEGDYIRHQH-GCCXERLZSA-N.
Keywords: | [Arg(Me2s)3]-Histone H4 (1-21)-GGK(Biotin), Ac-SG-R(me2s)-GKGGKGLGKGGAKRHRKV-GGK(Biotin), Histone H4 (1-21) (Arg3me2s), N2-(N2-acetyl-L-serylglycyl-Nomega,Nomega'-dimethyl-L-arginylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycy |
Supplier: | Cayman Chemical |
Supplier-Nr: | 28192 |
Properties
Application: | Biotinylated peptide fragment |
Conjugate: | No |
MW: | 2630.1 D |
Formula: | C111H197N43O29S . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K11254 | Matching products |
UniProt ID : | P62805 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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