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Product information "[Asp371]-Tyrosinase (369-377) (human) (trifluoroacetate salt)"
[Asp371]-Tyrosinase (369-377) is a naturally occurring tyrosinase antigen peptide. It is formed via post-translational modification of Asn371. [Asp371]-Tyrosinase (369-377) binds to MHC class I subtype HLA-A*0201-positive T2 cells (IC50 = 1.2 µg/ml) and induces lysis of HLA-A2.1-positive T2 cells incubated with cytotoxic T lymphocytes in a concentration-dependent manner. Immunization with [Asp371]-tyrosinase (369-377)-pulsed, CD40L-activated autologous dendritic cells delays tumor growth in an AAD-expressing B16-F1 melanoma model using transgenic mice expressing HLA-A*0201 linked to the CD8-binding domain of H-2Dd (AAD).Formal Name: (2S,5S,8S,11S,14S,20S)-20-((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-4-(methylthio)butanamido)-5-(3-amino-3-oxopropyl)-14-((R)-1-hydroxyethyl)-8-(hydroxymethyl)-2-isopropyl-11-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid, trifluoroacetate salt. Synonyms: [Asp370]-Tyrosinase (368-376), Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val. Molecular Formula: C42H66N10O16S2 . XCF3COOH. Formula Weight: 1031.2. Purity: >98% (mixture of isomers). Formulation: (Request formulation change), A solid. Peptide Sequence: YMDGTMSQV-OH. Solubility: Water: Soluble. SMILES: O=C(N[C@H](C(O)=O)C(C)C)[C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCSC)NC([C@H]([C@H](O)C)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@@H](N)CC(C=C1)=CC=C1O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C42H66N10O16S2.C2HF3O2/c1-20(2)33(42(67)68)52-39(64)25(10-11-30(44)56)47-40(65)29(19-53)50-38(63)27(13-15-70-5)48-41(66)34(21(3)54)51-31(57)18-45-36(61)28(17-32(58)59)49-37(62)26(12-14-69-4)46-35(60)24(43)16-22-6-8-23(55)9-7-22,3-2(4,5)1(6)7/h6-9,20-21,24-29,33-34,53-55H,10-19,43H2,1-5H3,(H2,44,56)(H,45,61)(H,46,60)(H,47,65)(H,48,66)(H,49,62)(H,50,63)(H,51,57)(H,52,64)(H,58,59)(H,67,68),(H,6,7)/t21-,24+,25+,26+,27+,28+,29+,33+,34+,/m1./s1. InChi Key: TWALUFAMCVRLBU-GPCYTBFMSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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