Adrenomedullin (13-52) (human) (trifluoroacetate salt)

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) (Cay-24889). It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II (Cay-17150) and endothelin-1 (Cay-24127) from isolated rat aorta. In vivo, adrenomedullin (13-52) decreases mean arterial pressure (MAP) in spontaneously and renal hypertensive rats in a dose-dependent manner. Adrenomedullin (13-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 (Cay-16450) in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure. It also potentiates inflammatory edema and neutrophil accumulation in rats.Formal Name: L-seryl-L-phenylalanylglycyl-L-cysteinyl-L-arginyl-L-phenylalanylglycyl-L-threonyl-L-cysteinyl-L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-lysyl-L-alpha-aspartyl-L-lysyl-L-alpha-aspartyl-L-asparaginyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-L-prolyl-L-glutaminylglycyl-L-tyrosinamide, cyclic (4->9)-disulfide, trifluoroacetate salt. Synonyms: ADM, AM. Molecular Formula: C200H308N58O59S2 . XCF3COOH. Formula Weight: 4533.1. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC(CNC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N3)CSSC[C@H](NC(CNC([C@@H](NC([C@H](CO)N[H])=O)CC4=CC=CC=C4)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CC8=CC=CC=C8)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C200H308N58O59S2.C2HF3O2/c1-16-101(9)157(254-176(295)126(64-68-147(209)270)233-179(298)133(83-113-88-216-97-222-113)237-163(282)103(11)223-177(296)128(77-98(3)4)239-168(287)117(45-27-31-69-201)227-173(292)125(63-67-146(208)269)236-191(310)156(100(7)8)252-196(315)161(107(15)264)256-187(306)141-96-319-318-95-140(226-150(273)90-220-166(285)129(238-164(283)116(205)92-259)79-108-39-21-18-22-40-108)186(305)231-121(49-35-73-217-199(212)213)171(290)240-130(80-109-41-23-19-24-42-109)167(286)221-91-151(274)250-159(105(13)262)194(313)249-141)192(311)245-131(82-112-55-59-115(266)60-56-112)178(297)232-124(62-66-145(207)268)174(293)241-132(81-110-43-25-20-26-44-110)183(302)255-160(106(14)263)195(314)246-137(87-154(279)280)181(300)229-119(47-29-33-71-203)169(288)243-135(85-152(275)276)180(299)228-118(46-28-32-70-202)170(289)244-136(86-153(277)278)182(301)242-134(84-148(210)271)184(303)251-155(99(5)6)190(309)224-104(12)197(316)257-75-37-51-142(257)188(307)234-122(50-36-74-218-200(214)215)172(291)247-138(93-260)185(304)230-120(48-30-34-72-204)175(294)253-158(102(10)17-2)193(312)248-139(94-261)198(317)258-76-38-52-143(258)189(308)235-123(61-65-144(206)267)165(284)219-89-149(272)225-127(162(211)281)78-111-53-57-114(265)58-54-111,3-2(4,5)1(6)7/h18-26,39-44,53-60,88,97-107,116-143,155-161,259-266H,16-17,27-38,45-52,61-87,89-96,201-205H2,1-15H3,(H2,206,267)(H2,207,268)(H2,208,269)(H2,209,270)(H2,210,271)(H2,211,281)(H,216,222)(H,219,284)(H,220,285)(H,221,286)(H,223,296)(H,224,309)(H,225,272)(H,226,273)(H,227,292)(H,228,299)(H,229,300)(H,230,304)(H,231,305)(H,232,297)(H,233,298)(H,234,307)(H,235,308)(H,236,310)(H,237,282)(H,238,283)(H,239,287)(H,240,290)(H,241,293)(H,242,301)(H,243,288)(H,244,289)(H,245,311)(H,246,314)(H,247,291)(H,248,312)(H,249,313)(H,250,274)(H,251,303)(H,252,315)(H,253,294)(H,254,295)(H,255,302)(H,256,306)(H,275,276)(H,277,278)(H,279,280)(H4,212,213,217)(H4,214,215,218),(H,6,7)/t101-,102-,103-,104-,105+,106+,107+,116-,117-,118-,119-,120-,121-,122-,123-,124-,1. InChi Key: ZFOARKDSHPKCOT-ZBKJENTOSA-N.