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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-RPES4319.50 | 50 µg | - | - | - |
9 - 20 business days* |
1,015.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human KEAP1/INRF2 Recombinant Protein (RPES4319) is a highly pure recombinant protein developed... more
Product information "Recombinant Human KEAP1/INRF2 Protein (His & GST & AVI Tag) (RPES4319)"
Human KEAP1/INRF2 Recombinant Protein (RPES4319) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). [The UniProt Consortium]
Keywords: | INrf2, Kelch-like protein 19, Cytosolic inhibitor of Nrf2, Kelch-like ECH-associated protein 1 |
Supplier: | Assay Genie |
Supplier-Nr: | RPES4319 |
Properties
Conjugate: | No |
Host: | Insect cells |
Species reactivity: | human |
Format: | Highly Purified |
Database Information
KEGG ID : | K10456 | Matching products |
UniProt ID : | Q14145 | Matching products |
Gene ID | GeneID 9817 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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