IL-1 alpha, Human

Sequence: MSAPFSFLSN VKYNFMRIIK YEFILNDALN QSIIRANDQY LTAAALHNLD EAVKFDMGAY KSSKDDAKIT VILRISKTQL DEDQPVLLKE MPEIPKTITG SETNLLFFWE THGTKNYFTS VAHPNLFIAT KQDYWVCLAG GPPSITDFQI with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. [The UniProt Consortium]