Galectin-3, His Tag, human recombinant (rHuGAL3-His)

Galectin-3, His Tag, human recombinant (rHuGAL3-His)
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
97308.5 5 µg - -

3 - 10 business days*

70.00€
97308.25 25 µg - -

3 - 10 business days*

180.00€
97308.1 1 mg - -

3 - 10 business days*

-
 
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the... more
Product information "Galectin-3, His Tag, human recombinant (rHuGAL3-His)"

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. (www.uniprot.org) Human recombinant LGALS3 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (fragment 1-250) and having a molecular mass of 28.2 kDa. The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus. Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.

Keywords: Galectin-3, GAL3, MAC2, CBP35, GALB, GALIG, LGALS2, LGALS3, Galactose-specific lectin 3, Mac-2 antigen, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, G
Supplier: Biomol GmbH
Supplier-Nr: 97308

Properties

Application: Bioassay
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 28200 D
Purity: >95%
Format: Purified

Database Information

KEGG ID : K06831 | Find alternatives
UniProt ID : P17931 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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