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IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3Kgamma and PI3Kdelta (IC50s = 0.24 and 50 nM, respectively). It is orally bioavailable and selective. As PI3Kgamma and PI3Kdelta are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models. It also has potential applications in immunotherapy and in certain cancers.Formal Name: 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone. CAS Number: 1201438-56-3. Synonyms: Duvelisib, INK1197. Molecular Formula: C22H17ClN6O. Formula Weight: 416.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 213, 239, 270, 344 nm. SMILES: C[C@@H](C1=CC(C=CC=C2Cl)=C2C(N1C3=CC=CC=C3)=O)NC4=C5C(N=CN5)=NC=N4. InChi Code: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1. InChi Key: SJVQHLPISAIATJ-ZDUSSCGKSA-N.
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