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IPI-145 is an inhibitor of p110 PI3K that exhibits anticancer chemotherapeutic, immunosuppressive, and anti-inflammatory activities. In clinical trials, IPI-145 displays potential benefit in the treatment of chronic lymphocytic leukemia (CLL). IPI-145 inhibits proliferation of B and T cells, inhibits neutrophil migration, and prevents basophil activation in vitro. In animal models of inflammatory diseases, IPI-145 decreases levels of matrix metalloproteinase 13 (MMP13) and IL-17, inhibiting Th17 T cell differentiation and decreasing arthritis severity and progression.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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