342 products were found matching "K00922"!

LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...

PI/PS (4:1, w/w) unilamellar vesicle, prepared with L-alpha-phosphatidylinositol (Liver, Bovine) (sodium salt) and L-alpha-phosphatidylserine (Brain, Porcine) (sodium salt). Lipid monolayer was formed by sonication. Application: Useful as a substrate for PI-3 kinase activity assays and other lipid kinases....

By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...

Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....

Protein function: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to...

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate PtdIns,PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical...

Parsaclisib is an inhibitor of PI3Kdelta (IC50 = 1 nM). It is selective for PI3Kdelta over PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >10,000 nM for all), as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 µM. Parsaclisib inhibits the proliferation of primary human B...

Tenalisib is an inhibitor of PI3Kdelta and PI3Kgamma (IC50s = 24.5 and 33.2 nM, respectively). It is greater than 300- and 120-fold selective for PI3Kdelta and PI3Kgamma, respectively, over PI3Kalpha and PI3Kbeta. Tenalisib (10 µM) induces cell death in L-540, KM-H2, and L-428 Hodgkin lymphoma cells. It induces cell...

NVP-BEZ235 is a dual inhibitor of class I PI3Ks (IC50s = 4, 75, 7, and 5 nM, for p110alpha, - beta, -delta, and -gamma, respectively) and mTOR (IC50 = 20 nM). It is selective for these enzymes over a panel of kinases (IC50s = >10 µM for all). NVP-BEZ235 (0.1 or 1 µM) inhibits proliferation of, and induces apoptosis...

Description: 3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kgamma (IC50 = 60 µM) and class III VPS34 (IC50 = 25 µM). 3-Methyladenine inhibits autophagy. Target: PI3K, Autophagy, Mitophagy, Endogenous Metabolite. Smiles: Cn1cnc(N)c2ncnc12. References: Hou H, et al. Inhibitors of...

Description: Selective PI3Kdelta Inhibitor 1 is a PI3Kdelta Inhibitor( IC50 = 0.9 nM). Target: PI3K. Smiles: CN1C(C2(CC2)C3=CC=CC=C3)=NC(=N1)C4=NC(=C(N)N=C4)C5=CC(F)=C(C(N)=O)C=C5. References: Terstiege I , Perry M , Petersen J , et al. Discovery of triazole aminopyrazines as a highly potent and selective series of...

Description: AS-252424 is a potent and selective inhibitor of PI3Kgamma with an IC50 of 33 nM and demonstrates over 10-fold selectivity for PI3Kgamma versus PI3Kalpha. Target: Casein Kinase, PI3K. Smiles: Oc1cc(F)ccc1-c1ccc(\C=C2/SC(=O)NC2=O)o1. References: Pomel V, et al, J Med Chem, 2006, 49(13), 3857-3871.