- Search results for K00922
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289 products were found matching "K00922"!
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Item number: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
Keywords: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
Application: | PI3K inhibitor |
CAS | 154447-36-6 |
MW: | 307.3 D |
From 35.00€
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Item number: BPS-40560
PI/PS (4:1, w/w) unilamellar vesicle, prepared with L-alpha-phosphatidylinositol (Liver, Bovine) (sodium salt) and L-alpha-phosphatidylserine (Brain, Porcine) (sodium salt). Lipid monolayer was formed by sonication. Application: Useful as a substrate for PI-3 kinase activity assays and other lipid kinases....
Application: | PI-3 kinase substrate |
569.00€
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Item number: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
Keywords: | KY 12420,... |
Application: | PI3K inhibitor |
CAS | 19545-26-7 |
MW: | 428.4 D |
From 60.00€
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Item number: Cay13242-25
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....
Keywords: | 3-MA, NSC 66389, 3-methyl-3H-purin-6-amine |
Application: | PI3K inhibitor |
CAS | 5142-23-4 |
MW: | 149.2 D |
From 44.00€
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Item number: NSJ-F54959-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
Keywords: | Anti-PIK3CD, Anti-p110delta, Anti-PI3Kdelta, Anti-PI3K-delta, Anti-PI3-kinase subunit delta, Anti-PtdIns-3-kinase subunit... |
Application: | IF, WB, IHC (paraffin) |
Host: | Rabbit |
Species reactivity: | human |
From 326.00€
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Item number: Cay37576-1
Inavolisib is an inhibitor of PI3Kalpha (Ki = 0.034 nM). It is selective for PI3Kalpha over PI3Kbeta, PI3Kdelta, and PI3Kgamma (Kis = 99.7, 12.2, and 18.2 nM, respectively) and is 4.4-fold selective in decreasing the phosphorylated levels of proline-rich Akt substrate 40 kDa (PRAS40) in HCC1954 breast cancer cells,...
Keywords: | GDC-0077, RG-6114,... |
Application: | PI3Kalpha inhibitor |
CAS | 2060571-02-8 |
MW: | 407.4 D |
From 80.00€
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Item number: Cay39527-1
PF-04979064 is a dual inhibitor of PI3K and mTOR (Kis = 0.13, 0.111, 0.122, and 1.42 nM for PI3Kalpha, PI3Kgamma, PI3Kdelta, and mTOR, respectively). It is selective for PI3K and mTOR over a panel of 36 other kinases at 1 µM. PF-04979064 inhibits phosphorylation of Akt in BT-20 breast cancer cells (IC50 = 9.1 nM)....
Keywords: | 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]napht... |
Application: | PI3K / mTOR dual inhibitor |
CAS | 1220699-06-8 |
MW: | 446.5 D |
From 35.00€
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Item number: ELK-ELK3401.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PIK3Cd. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PIK3Cd....
Keywords: | PIK3CD, p110delta, PI3Kdelta, PI3K-delta, PI3-kinase subunit delta, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: ELK-ELK0899.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PIK3C2a. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PIK3C2a. Next,...
Keywords: | p110alpha, PI3Kalpha, PI3K-alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit... |
Application: | ELISA |
Species reactivity: | rat |
From 365.00€
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Item number: ELK-ELK3671.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PIK3Cb. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PIK3Cb....
Keywords: | PIK3CB, PIK3C1, PI3Kbeta, p110beta, PI3K-beta, PI3-kinase subunit beta, PtdIns-3-kinase subunit beta, PtdIns-3-kinase... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay39118-1
UCL-TRO-1938 is an allosteric activator of PI3Kalpha. It binds to PI3Kalpha in a surface plasmon resonance (SPR) assay (Kd = 36 µM) and induces PI3Kalpha activation in a cell-free assay when used at concentrations of 25 and 50 µM, an effect that can be reversed by the PI3Kalpha inhibitor BYL719 (Cay-16986)....
Keywords: | 1-[7-[[2-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyridinyl]amino]-2,3-dihydro-1H-indol-1-yl]-ethanone |
Application: | Allosteric PI3Kalpha activator |
CAS | 2919575-27-0 |
MW: | 456.6 D |
From 35.00€
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Item number: Cay10565-25
NVP-BEZ235 is a dual inhibitor of class I PI3Ks (IC50s = 4, 75, 7, and 5 nM, for p110alpha, - beta, -delta, and -gamma, respectively) and mTOR (IC50 = 20 nM). It is selective for these enzymes over a panel of kinases (IC50s = >10 µM for all). NVP-BEZ235 (0.1 or 1 µM) inhibits proliferation of, and induces apoptosis...
Keywords: | Dactolisib,... |
Application: | PI3K and mTOR inhibitor |
CAS | 915019-65-7 |
MW: | 469.5 D |
From 60.00€
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