Other Cell-Based Assays

Cayman's Extracellular Oxygen Consumption Assay Kit uses a phosphorescent oxygen-sensitive probe. Because of its inability to cross the membrane, the probe selectively reports on changes in oxygen levels in the medium. The probe's signal is quenched upon binding to oxygen, resulting in a signal that is inversely...

Nicotinamide adenine dinucleotide (NAD) exists in an oxidized form, NAD+, as well as a reduced form, NADH. NAD, the main free form in cells, functions in modulating cellular redox status and by controlling signaling and transcriptional events, making it an important cofactor when investigating normal cellular...

Cayman's Hydrogen Peroxide Assay Kit provides a simple method for the sensitive quantitation of extracellular H2O2 produced by cultured cells. H2O2 is detected using ADHP (10-acetyl-3,7-dihydroxyphenoxazine), a highly sensitive and stable probe for H2O2. In a horseradish peroxidase catalyzed reaction, ADHP reacts...

hMOR1, also known as the Human Mu Opioid Receptor (MOR1), is a key member of the G-protein coupled receptor (GPCR) family. hMOR1 is a critical target for opioid-based analgesics and is implicated in various disorders, including chronic pain, opioid addiction, and other neurological conditions. Traditional methods...

hKOR, also known as the Human Kappa Opioid Receptor, is a key member of the G-protein coupled receptor (GPCR) family, involved in various neurological and psychiatric conditions, including pain management, depression, and addiction. Traditional methods for studying GPCRs often fail to address the full spectrum of...

Somatostatin receptor 1 (SSTR1), a key GPCR, plays an essential role in regulating endocrine and nervous system functions by inhibiting adenylyl cyclase activity and decreasing intracellular cAMP levels. Dysregulated SSTR1 signaling is associated with various conditions, including neuroendocrine tumors, pituitary...

CCR3 or Chemokine (CC) receptor type 3, a key member of the GPCR family, is critically involved in various inflammatory and allergic conditions, including asthma, eosinophilic disorders, and certain autoimmune diseases, making it an important therapeutic target. Traditional methods for studying GPCRs often fail to...

CXCR2 or C-X-C motif chemokine receptor 2 belongs to the GPCR family, and plays a pivotal role in immune responses by mediating the effects of various chemokines. CXCR2 is implicated in various inflammatory, immune, and pathological conditions, including neutrophil recruitment, cancer progression, and angiogenesis,...

Nociceptin/Orphanin FQ Peptide Receptor (NOP) is a member of the opioid receptor family that is involved in regulating pain, anxiety, stress, and other physiological processes. Unlike classical opioid receptors, NOP signaling does not mediate typical opioid-induced analgesia, euphoria and respiratory depression,...

hDOR, also known as the Human Delta Opioid Receptor, is a key member of the G-protein coupled receptor (GPCR) family. It plays an essential role in modulating analgesia, mood regulation, and neuroprotection. hDOR is implicated in various conditions, including chronic pain, depression, and neurodegenerative...

Vasopressin receptor 2 (V2R), a key GPCR, regulates water homeostasis and fluid balance by activating adenylyl cyclase and increasing intracellular cAMP upon vasopressin binding. Dysregulation of V2R signaling is linked to conditions such as diabetes insipidus, hypertension, and heart failure. Traditional methods...

CCR2B or Chemokine (CC) receptor type 2B, a key member of the GPCR family, is implicated in a variety of inflammatory, autoimmune diseases, cancer, fibrosis, and other pathological conditions, making it a vital therapeutic target. Traditional methods for studying GPCRs often fail to address the signaling mechanisms...