Other Cell-Based Assays

Excitation (nm): 490. Emission (nm): 525. Quantum yield: 0.95. G protein coupled receptors (GPCR) are one of the largest receptor classes targeted by drug discovery programs. Calcium flux (coupled via Gq pathway) assay is a preferred method in drug discovery for screening GPCR targets. However, over 60% of the known...

Excitation: FITC filter set. Emission: FITC filter set. Virtually all G protein coupled receptors (GPCRs) rapidly undergo desensitization by a common pathway upon activation by ligand binding. The binding of beta-arrestin, a cytoplasmic protein, to an activated receptor deactivates the GPCR signaling and initiates...

Excitation: FITC filter set. Emission: FITC filter set. Virtually all G protein coupled receptors (GPCRs) rapidly undergo desensitization by a common pathway upon activation by ligand binding. The binding of beta-arrestin, a cytoplasmic protein, to an activated receptor deactivates the GPCR signaling and initiates...

Almost all plasma membranes have an electrical potential across them, with the inside usually negative with respect to the outside. Signals are generated by opening or closing of ion channels at one point in the membrane, producing a local change in the membrane potential. This change in the electric field can be...

Detection principle: Abnormal accumulation of cellular cuprous in cells induces the oligomerization of key components of the lipoic acid-modified pyruvate dehydrogenase complex, which affects the tricarboxylic acid cycle, triggers proteotoxic stress, and induces cell death. Cellular cuprous can catalyze the...

Detection principle: Elabscience(R) 2-NBDG Glucose Uptake Cell-Based Kit provides the green fluorescently labeled glucose tracer 2-NBDG, which can be used in flow cytometry and fluorescence microscopy to detect the glucose uptake viability of cells. General Information: Application Glucose Uptake Detection method...

Introduction: The ability of TH cells, also known as helper T cells, to differentiate into Th1, Th2, and Th17 cells is very weak at rest. There are only a very small number of Th1, Th2, and Th17 cells in the peripheral blood, when Th cells are stimulated by external factors, TH0 will differentiate into Th1, Th2 or...

Introduction: The ability of TH cells, also known as helper T cells, to differentiate into Th1, Th2, and Th17 cells is very weak at rest. There are only a very small number of Th1, Th2, and Th17 cells in the peripheral blood, when Th cells are stimulated by external factors, TH0 will differentiate into Th1, Th2 or...

Introduction: The ability of TH cells, also known as helper T cells, to differentiate into Th1, Th2, and Th17 cells is very weak at rest. There are only a very small number of Th1, Th2, and Th17 cells in the peripheral blood, when Th cells are stimulated by external factors, TH0 will differentiate into Th1, Th2 or...

Introduction: The ability of TH cells, also known as helper T cells, to differentiate into Th1, Th2, and Th17 cells is very weak at rest. There are only a very small number of Th1, Th2, and Th17 cells in the peripheral blood, when Th cells are stimulated by external factors, TH0 will differentiate into Th1, Th2 or...

Introduction: Mouse Bone Marrow-derived Dendritic Cells (BMDC) Differentiation and Culture Kit includes Mouse DC Cell Differentiation MIX(1000X) and Mouse DC Cell Maturation MIX(1000X),which has been developed for the in vitro culture and differentiation of Mouse Bone Marrow Cells into dendriticcells (DCs) and their...