Cell Meter(TM) Caspase 8 Activity Apoptosis Assay Kit (Red Fluorescence)

Cell Meter(TM) Caspase 8 Activity Apoptosis Assay Kit (Red Fluorescence)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-22816 100 tests -

3 - 8 business days*

230.00€
 
Our Cell Meter(TM) assay kits are a set of tools for monitoring cellular functions. There are a... more
Product information "Cell Meter(TM) Caspase 8 Activity Apoptosis Assay Kit (Red Fluorescence)"
Our Cell Meter(TM) assay kits are a set of tools for monitoring cellular functions. There are a variety of parameters that can be used to monitor cell apoptosis. This particular kit is designed to monitor cell apoptosis by measuring caspase 8 activity. Caspase 8 is a caspase protein, encoded by the CASP8 gene. Caspase 8 also plays an important role in neurodegenerative diseases such as Huntington disease. Caspase 8 is proven to have substrate selectivity for the peptide sequence Ile-Glu-Thr-Asp (IETD). This kit uses (Ac-IETD)-ProRed(TM) as a fluorogenic indicator for caspase 8 activity. Cleavage of ProRed(TM) peptides by caspase 8 generates strongly fluorescent ProRed(TM) which is monitored at Ex/Em = 530/620 nm. This spectral feature makes the kit compatible with the DAPI filter set. The kit provides all the essential components with an optimized assay protocol. The assay can be readily adapted for high throughput screenings. It can be used to either quantify the activated caspase 8 activities in apoptotic cells or screen the caspase 8 inhibitors.
Keywords: CAP4, MCH5, MACH, CASP8, FLICE, CASP-8, Caspase-8, EC=3.4.22.61, FADD-like ICE, Caspase-8 subunit p18, Caspase-8 subunit p10, Apoptotic protease Mch-5, Apoptotic cysteine protease, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Supplier: AAT Bioquest
Supplier-Nr: 22816

Properties

Application: Caspase-8 assays
Format: Homog.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Signal Word: Warning
Caution
Our products are for laboratory research use only: Not for administration to humans!
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