Phospho-JNK Antibody Duo (Total, pT183/Y185)

Phospho-JNK Antibody Duo (Total, pT183/Y185)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG30294.1 1 pair - -

6 - 14 business days*

752.00€
 
Protein function: Serine/threonine-protein kinase involved in various processes such as cell... more
Product information "Phospho-JNK Antibody Duo (Total, pT183/Y185)"
Protein function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). [The UniProt Consortium]
Keywords: Anti-phospho-JNK2, Anti-phospho-MAPK9, Anti-phospho-JNK-55, Anti-phospho-MAPK 9, Anti-phospho-SAPK1a, EC=2.7.11.24, Anti-phospho-MAP kinase 9, Anti-phospho-c-Jun N-terminal kinase 2, Anti-phospho-Stress-activated protein kinase 1a
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG30294

Properties

Antibody Type: Mixed
Conjugate: No

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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