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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-H38S | 25 µl | - | - |
6 - 10 business days* |
180.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
STAT2 pS734 affinity purified antibody is directed against human STAT2 protein. The product was... more
Product information "Anti-phospho-STAT2 (Ser734)"
STAT2 pS734 affinity purified antibody is directed against human STAT2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with STAT2 pS734 protein from human and monkey sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known. STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. STAT2pS734 antibody is ideal for researchers focused in cancer and transcripton factor research.
Keywords: | Anti-phospho-p113, Anti-phospho-STAT2, Anti-phospho-Signal transducer and activator of transcription 2 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-H38S |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, monkey |
Immunogen: | phosphorylated synthetic peptide corresponding to serine 734 a region near the C-terminus of human STAT2 protein. |
Format: | Purified |
Database Information
KEGG ID : | K11221 | Matching products |
UniProt ID : | P52630 | Matching products |
Gene ID | GeneID 6773 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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