Anti-phospho-IRE1a (Ser724)

Anti-phospho-IRE1a (Ser724)
Anti-phospho-IRE1a (Ser724)
   
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG40603.50 50 µl - -

6 - 14 business days*

30 %
496.00€
347.20€
 
Protein function: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor... more
Product information "Anti-phospho-IRE1a (Ser724)"
Protein function: Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). [The UniProt Consortium]
Keywords: Anti-phospho-IRE1a, Anti-phospho-hIRE1p, Anti-phospho-Ire1-alpha, Anti-phospho-Endoribonuclease, Anti-phospho-Inositol-requiring protein 1, Anti-phospho-Serine/threonine-protein kinase, Anti-phospho-Endoplasmic reticulum-to-nucleus signaling 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG40603

Properties

Application: IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Phosphospecific peptide around Ser724 of Human IRE1a
MW: 109 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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