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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C0026-09D.100 | 100 µl | - | - |
3 - 19 business days* |
757.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but lacks tyrosine... more
Product information "Anti-phospho-ErbB3 (Tyr1222) (c-erbB3, HER3)"
HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2 and the p85 subunit of PI3 kinase, which mediate ErbB- downstream signaling. Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3 kinase. ErbB3 is highly expressed in many cancer cells and activation of ErbB3-PI3 kinase pathway is correlated with malignant phenotypes of adenocarcinomas. In tumor development, ErbB3 may function as an oncogenic unit together with other ErbB members, e.g. ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Thus, prevention of the interaction of ErbB3 with other ErbB tyrosine kinases has become a novel anti-tumor strategy. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-HER3, Anti-ERBB3, EC=2.7.10.1, Anti-Proto-oncogene-like protein c-ErbB-3, Anti-Receptor tyrosine-protein kinase erbB-3, Anti-Tyrosine kinase-type cell surface receptor HER3 |
Supplier: | United States Biological |
Supplier-Nr: | C0026-09D |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 7H10(50C2) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthetic phospho-peptide (KLH-coupled) corresponding to residues surrounding Tyr1222 of human HER3/ErbB3. |
Format: | Supernatant |
Database Information
KEGG ID : | K05084 | Matching products |
UniProt ID : | P21860 | Matching products |
Gene ID | GeneID 2065 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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