204 products were found matching "K05084"!

ErbB3 is one of four alphaembers of the epidermal growth factor (EGF) receptor family with no intrinsic kinase activity. Therefore, its signal transduction upon EGF ligand binding is carried by the heterodimerization of ErbB3 with a different EGF receptor kinase. ErbB3 is linked to cancer etiology and progression....

Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase...

Patritumab (BPS Bioscience #84316) is a component of the ADC(antibody drug conjugate) Patritumab Deruxtecan (BPS Bioscience #84315) and also functions as neutralizing monoclonal antibody targeting HER3 (human epidermal growth factor receptor 3). HER3 (human epidermal growth factor receptor 3) is a transmembrane...

Anti-HER3 (human epidermal growth factor receptor 3) antibody Ab562 is a monoclonal antibody that is part of the ADC (antibody drug conjugate) AMT-562. HER3 (human epidermal growth factor receptor 3) is a transmembrane protein encoded by the ERB3 gene. HER3 is broadly expressed in human tissues however, increased...

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation....

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated...

Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase...

TX1-85-1 is an inhibitor of the epidermal growth factor receptor tyrosine kinase ErbB3 (IC50 = 23 nM). It also binds to ErbB2, Lyn, and several other Src family kinases in a live cell chemical proteomics assay when used at a concentration of 2 µM. TX1-85-1 inhibits phosphorylation of Akt and ERK1/2 in...

Recombinant Human HER3 protein with C-terminal 6×His tag. HER3(Ser20-Thr643) 6×His tag, Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues...

Protein function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it, ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase...

Protein function: Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. [The UniProt Consortium]

Protein function: Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5. [The UniProt Consortium]