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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D1150-05A-FITC.200 | 200 µl | - | - |
3 - 19 business days* |
993.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to... more
Product information "Anti-phospho-DAXX (Ser213) (Death Domain-associated Protein 6, Daxx, hDaxx, Fas Death Domain-associa"
DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Applications: Suitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: | Anti-phospho-EAP1, Anti-phospho-Daxx, Anti-phospho-DAXX, Anti-phospho-BING2, Anti-phospho-hDaxx, Anti-phospho-ETS1-associated protein 1, Anti-phospho-Death domain-associated protein 6, Anti-phospho-Fas death domain-associated protein |
Supplier: | United States Biological |
Supplier-Nr: | D1150-05A-FITC |
Properties
Application: | FLISA, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | FITC |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser213 of human DAXX (KLH). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K02308 | Matching products |
UniProt ID : | Q9UER7 | Matching products |
Gene ID | GeneID 1616 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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