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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F48749-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F48749-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene generates several transcript variants which... more
Product information "Anti-phospho-CDKN2A (Ser8)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. Protein function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. [The UniProt Consortium]
Keywords: | Anti-phospho-MTS-1, Anti-phospho-CDKN2, Anti-phospho-CDK4I, Anti-phospho-p16-INK4, Anti-phospho-p16INK4A, Anti-phospho-p16-INK4a, Anti-phospho-Multiple tumor suppressor 1, Anti-phospho-Cyclin-dependent kinase inhibitor 2A, Phospho-CDKN2A Antibody (pS8) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F48749 |
Properties
Application: | DB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS8 of human CDKN2A. |
Format: | Purified |
Database Information
KEGG ID : | K06621 | Matching products |
UniProt ID : | P42771 | Matching products |
Gene ID | GeneID 1029 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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