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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-35-1260-100 | 100 µg | - |
3 - 11 business days* |
682.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
SncA is a member of the synuclein family of structurally related proteins that are prominently... more
Product information "Anti-phospho-Alpha-Synuclein (Tyr133)"
SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons Protein function: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. [The UniProt Consortium]
Keywords: | Anti-phospho-SNCA, Anti-phospho-NACP, Anti-phospho-Alpha-synuclein, Anti-phospho-Non-A beta component of AD amyloid, Anti-phospho-Non-A4 component of amyloid precursor, Polyclonal Antibody to Alpha-Synuclein (Phospho-Tyr133) |
Supplier: | Abeomics |
Supplier-Nr: | 35-1260 |
Properties
Application: | WB, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Peptide sequence around phosphorylation site of tyrosine 133 (E-G-Y(p)-Q-D) derived from Human a-Synuclein. |
Format: | Purified |
Database Information
KEGG ID : | K04528 | Matching products |
UniProt ID : | P37840 | Matching products |
Gene ID | GeneID 6622 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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