iFluor(TM) 568 Anti-human CD279 Antibody *J110*

iFluor(TM) 568 Anti-human CD279 Antibody *J110*
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-127920B0 100 tests -

3 - 8 business days*

356.00€
ABD-127920B1 500 tests -

3 - 8 business days*

1,335.00€
 
Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in... more
Product information "iFluor(TM) 568 Anti-human CD279 Antibody *J110*"
Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. [The UniProt Consortium]
Keywords: Anti-CD279, Anti-hPD-1, Anti-Protein PD-1, Anti-Programmed cell death protein 1
Supplier: AAT Bioquest
Supplier-Nr: 127920B

Properties

Application: FC, IF
Antibody Type: Monoclonal
Clone: J110
Conjugate: iFluor 568
Host: Mouse
Reactivity: Human
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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