Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-7571-25 | 25 µg | - |
3 - 11 business days* |
149.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Villin is a protein that belongs to the gelsolin family of calcium-regulated actin-binding... more
Product information "Anti-Villin (Clone: ABM4E64)"
Villin is a protein that belongs to the gelsolin family of calcium-regulated actin-binding proteins. It is expressed in differentiated epithelial cells with a brush border such as intestinal villi, proximal renal tubules, oviduct, and seminiferous ducts. Villin shares structural and functional homology with two conserved families of proteins. One family of proteins, which includes gelsolin and adseverin, shares the conserved domain(s) found in the villin core. Villin regulates cell migration, cell death, and epithelial-to-mesenchymal transition underscoring the significance of this protein to epithelial cell function. Protein function: Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA), binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. [The UniProt Consortium]
Keywords: | Anti-VIL, Anti-VIL1, Anti-Villin-1, Monoclonal Antibody to Villin (Clone: ABM4E64) |
Supplier: | Abeomics |
Supplier-Nr: | 10-7571-25 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | ABM4E64 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant Villin protein (amino acids 108-322) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05761 | Matching products |
UniProt ID : | P09327 | Matching products |
Gene ID | GeneID 7429 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
-30 %
Discount Promotion
-30 %
Discount Promotion
Viewed