Anti-VEGF (Vascular Endothelial Growth Factor), clone SPM225

Anti-VEGF (Vascular Endothelial Growth Factor), clone SPM225
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2926-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V2926-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb recognizes proteins of... more
Product information "Anti-VEGF (Vascular Endothelial Growth Factor), clone SPM225"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb recognizes proteins of 19-22kDa (reducing) and 38kDa-44kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis. Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. [The UniProt Consortium]
Keywords: Anti-VPF, Anti-VEGF, Anti-VEGFA, Anti-VEGF-A, Anti-Vascular permeability factor, Anti-Vascular endothelial growth factor A, VEGF Antibody (Vascular Endothelial Growth Factor)
Supplier: NSJ Bioreagents
Supplier-Nr: V2926-20UG

Properties

Application: IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM225
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat, Rabbit, Dog
Immunogen: Human VEGF189 recombinant protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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