Anti-Varp

Anti-Varp
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-998A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-998A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-998A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate... more
Product information "Anti-Varp"
Protein function: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events, in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes, the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth, the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface, the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking, the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. [The UniProt Consortium]
Keywords: Anti-ANKRD27, Anti-PP12899, Anti-VPS9 domain-containing protein, Anti-Ankyrin repeat domain-containing protein 27
Supplier: Bethyl Laboratories
Supplier-Nr: A302-998A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-998A-T maps to a region between residue 1000 and 1050 of human Vps9 Domain and Ankyrin-Repeat-Containing Protein using the numbering given in entry NP_115515.2 (GeneID 84079).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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