Protein function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. [The UniProt Consortium]
Human, Mouse (Expected: Rat, Bovine, Dog, Rabbit, Pig, Panda, Orangutan, Gorilla, White-tufted-ear Marmoset, African Elephant, Chinese Hamster, Naked Mole Rat, Thirteen-lined Ground Squirrel, Little Brown Bat)
synthetic peptide. The epitope recognized by A301-351A-T maps to a region between residue 2497 and 2547 of human ubiquitin specific peptidase 9, X-linked using the numbering given in entry CAD18900.2 (GeneID 8239).