Protein function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. [The UniProt Consortium]
Human (Expected: Mouse, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, White-tufted-ear Marmoset, Crab-eating Macaque, European Domestic Ferret, African Elephant, Chinese Hamster, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A301-350A-T maps to a region between residue 625 and 675 of human ubiquitin specific peptidase 9, X-linked using the numbering given in entry CAD18900.2 (GeneID 8239).