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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
U1005-01B.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
UCH-L3 (Ubiquitin carboxyterminal hydrolase isozyme 3) is a 26-28kD member of the peptidase C12... more
Product information "Anti-UCHL3 (Ubiquitin Carboxyl-terminal Hydrolase Isozyme L3, UCH-L3, Ubiquitin Thioesterase L3)"
UCH-L3 (Ubiquitin carboxyterminal hydrolase isozyme 3) is a 26-28kD member of the peptidase C12 family of enzymes. It shows wide expression, being noted in adipocytes, renal duct epithelium, neurons, and striated muscle. UCH-L3 cleaves both monomeric ubiquitin (Ub) from Ub-protein conjugates, and a GGLRQ peptide from the C-terminus of the Ub-like protein NEDD-8. Notably, UCH-L3 activity is muted in the presence of Ub interacting dimers. Human UCH-L3 is 230aa in length. It is phosphorylated on Ser75 and Ser130, and contains two ubiquitin-binding sequences between aa40-57 and 178-186. Four potential splice forms have been reported. Two show a four aa deletion between aa15-18, with one also containing a 14aa substitution for aa179-230. Two others contain an alternative start site at Met37, one of which is also accompanied by a seven aa substitution for aa143-230. Full-length human UCH-L3 shares 98% aa identity with mouse and rat UCH-L3. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=3.4.19.12, Anti-Ubiquitin thioesterase L3, Anti-Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
Supplier: | United States Biological |
Supplier-Nr: | U1005-01B |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 10K29 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Purified, E.coli-derived recombinant human Ubiquitin carboxyterminal hydrolase isozyme 3. (UCH-L3, aa2-230, Accession #P15374). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05609 | Matching products |
UniProt ID : | P15374 | Matching products |
Gene ID | GeneID 7347 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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