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Discount Promotion
Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG43183.100 | 100 µl | - | - |
6 - 14 business days* |
30 %
|
624.00€
436.80€ |
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of... more
Product information "Anti-UBE2N / UBC13"
Protein function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'- linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1- UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'- linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1- UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'- linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. [The UniProt Consortium]
Keywords: | Anti-BLU, Anti-UBE2N, Anti-Ubc13, Anti-Ubc13, Anti-UbcH13, Anti-UbcH13, Anti-Ubiquitin-protein ligase N, Anti-Ubiquitin-protein ligase N, Anti-Ubiquitin carrier protein N, Anti-Ubiquitin carrier protein N, Anti-Ubiquitin-conjugating enzyme E2 N, Anti-E2 u |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG43183 |
Properties
Application: | ICC, IF, IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide derived from Human UBE2N / UBC13 |
MW: | 17 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K10580 | Matching products |
UniProt ID : | P61088 | Matching products |
Gene ID | GeneID 7334 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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