Protein function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). [The UniProt Consortium]
Anti-VDUP1, Anti-TXNIP, Anti-Thioredoxin-binding protein 2, Anti-Thioredoxin-interacting protein, Anti-Vitamin D3 up-regulated protein 1
synthetic peptide. The epitope recognized by A303-229A-T maps to a region between residue 300 and 350 of human Thioredoxin Interacting Protein using the numbering given in entry NP_006463.3 (GeneID 10628).