50 products were found matching "K20910"!

A TXNIP inhibitor, inhibits TXNIP promoter activity in a reporter assay using INS-1 cells expressing human TXNIP (IC50 = 0.64 µM), decreases the levels of TXNIP in the same cells in a concentration-dependent manner, induces glucagon secretion from TC-1 mouse lung cancer cells and decreases glucagon-induced glucose...

Protein function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a...

Anti-UBC13 Antibody is purified by ion exchange chromatography. Cross reactivity with UBC13 from other sources has not been determined. Protein function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced...

0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. TXNIP (Thioredoxin-interacting protein), also called VDUP1 (Vitamin D3 upregulated protein 1) is a member of the Arrestin family of signal transduction proteins. It is a potent tumor suppressor, blocking tumor growth via blocking cell cycle progression,...

In 1X PBS, pH 7.4, with 0.09% sodium azide. May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the...

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional...

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional...

In 1X PBS, pH 7.4, with 0.09% sodium azide. TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. It is mapped to 1q21.1. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is...

Protein function: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a...

SRI-37330 is an inhibitor of thioredoxin-interacting protein (TXNIP). It inhibits the expression of Txnip mRNA in INS-1 rat insulinoma cells (IC50 = 0.64 µM) and decreases Txnip protein levels in the same cells in a concentration-dependent manner. SRI-37330 (10 µM) inhibits LPS-induced pyroptosis in A549 cells...