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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T9160-38F.20 | 20 µl | - | - |
3 - 19 business days* |
439.00€
|
||
T9160-38F.100 | 100 µl | - | - |
3 - 19 business days* |
757.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
A20, also referred to as TNF-a-induced protein 3 (TNFAIP3), is cytokine-inducible protein that... more
Product information "Anti-Tumor Necrosis Factor alpha-Induced Protein 3 (TNF alpha-Induced Protein 3, TNFAIP3, A20, MGC10"
A20, also referred to as TNF-a-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kB. It was first identified as a TNF-a inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs. Constitutive expression of A20 is observed in lymphoid tissues, but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-a, IL-1, phorbol esters, and LPS. Expression of A20 can confer resistance to apoptosis and NF-kB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members, and interaction with the NF-kB inhibiting protein ABIN. Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions. The aminoterminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Immunoprecipitation: 1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=6.3.2.-, EC=3.4.19.12, Anti-Zinc finger protein A20, Anti-TNF alpha-induced protein 3, Anti-OTU domain-containing protein 7C, Anti-Putative DNA-binding protein A20, Anti-Tumor necrosis factor alpha-induced protein 3 |
Supplier: | United States Biological |
Supplier-Nr: | T9160-38F |
Properties
Application: | IP, WB |
Antibody Type: | Monoclonal |
Clone: | 11C1088(D13H3) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, monkey, mouse, rat |
Immunogen: | Recombinant fragment of A20/TNFAIP3 corresponding to the ovarian tumor (OTU) domain between aa92-263 of human A20/TNFAIP3. |
Format: | Purified |
Database Information
KEGG ID : | K11859 | Matching products |
UniProt ID : | P21580 | Matching products |
Gene ID | GeneID 7128 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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