Anti-Transferrin Receptor / CD71, clone TFRC/1396

Anti-Transferrin Receptor / CD71, clone TFRC/1396
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3294-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3294-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. It recognizes a... more
Product information "Anti-Transferrin Receptor / CD71, clone TFRC/1396"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). [The UniProt Consortium]
Keywords: Anti-TFRC, Transferrin Receptor Antibody / CD71
Supplier: NSJ Bioreagents
Supplier-Nr: V3294-20UG

Properties

Application: FC, IF, WB, IF
Antibody Type: Monoclonal
Clone: TFRC/1396
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human protein was used as the immunogen for the CD71 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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