Anti-SYCP3 (SCP3)

Anti-SYCP3 (SCP3)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30137 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Synaptonemal complex protein 3, also known... more
Product information "Anti-SYCP3 (SCP3)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Synaptonemal complex protein 3, also known as COR1 or SCP3, is in humans is encoded by the SYCP3 gene. This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein by dominant-negative interference. SYCP3 is linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes. Protein function: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2. [The UniProt Consortium]
Keywords: Anti-SCP3, Anti-SYCP3, Anti-SCP-3, Anti-Synaptonemal complex protein 3, SYCP3 Antibody (SCP3)
Supplier: NSJ Bioreagents
Supplier-Nr: R30137

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Human partial recombinant protein (AA 18-223) was used as the immunogen for this SYCP3 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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