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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7864SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. SOX2 is required for stem cell maintenance in the... more
Product information "Anti-SOX2, clone SOX2/3811R"
1 mg/ml in 1X PBS, BSA free, sodium azide free. SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker. Protein function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. [The UniProt Consortium]
Keywords: | Anti-SOX2, Anti-Transcription factor SOX-2, SOX2 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7864SAF |
Properties
Application: | ELISA, WB, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | SOX2/3811R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A recombinant human partial protein (amino acids 176-305) |
Format: | Purified |
Database Information
KEGG ID : | K16796 | Matching products |
UniProt ID : | P48431 | Matching products |
Gene ID | GeneID 6657 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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