Anti-Shh (Sonic HedgeHog)

Anti-Shh (Sonic HedgeHog)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S1012-96F.100 100 µl - -

1 - 19 business days

Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal... more
Product information "Anti-Shh (Sonic HedgeHog)"
Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal development. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers (1-2). The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh) and Desert (Dhh), all of which have distinct as well as overlapping roles (3-5). Hh proteins are synthesized as 45kD precursors that undergo auto-cleavage to generate a 19kD amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. This doubly modified Hh-N peptide is released from cells and responsible for all known Hedgehog signaling activity (6). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: S1012-96F


Application: WB
Antibody Type: Monoclonal
Clone: 8A36(C9C5)
Conjugate: No
Host: Rabbit
Reactivity: Human, Rat, Zebrafish
Immunogen: Synthetic peptide (KLH-coupled) corresponding to residues surrounding Glu53 of human Shh.

Database Information

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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