Anti-RPA32 / RPA2, clone 3E7-B5-F2

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Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG54148.100 100 µl - -

6 - 14 business days

483.00€
 
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds... more
Product information "Anti-RPA32 / RPA2, clone 3E7-B5-F2"
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. [The UniProt Consortium]
Keywords: Anti-RPA2, Anti-REPA2, Anti-RP-A p34, Anti-RP-A p32, Anti-RF-A protein 2, Anti-Replication factor A protein 2, Anti-Replication protein A 32 kDa subunit, Anti-Replication protein A 34 kDa subunit
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG54148100

Properties

Application: WB, IP, ICC, IF
Antibody Type: Monoclonal
Clone: 3E7-B5-F2
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant human RPA32/RPA2 protein fragments expressed in E.coli
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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