Anti-ROC1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-462A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-462A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-462A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin ligase component of multiple cullin-RING- based E3... more
Product information "Anti-ROC1"
Protein function: E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription- coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (PubMed:27565346). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. [The UniProt Consortium]
Keywords: Anti-RBX1, Anti-RNF75
Supplier: Bethyl Laboratories
Supplier-Nr: A303-462A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Chicken, Turkey, Bovine, Dog, Horse, Guinea Pig_10141, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Tasmanian Devil, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-462A-T maps to a region between residue 1 and 50 of human Regulator of Cullins 1 using the numbering given in entry NP_055063.1 (GeneID 9978).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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