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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-038A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-038A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD)... more
Product information "Anti-RENT1"
Protein function: RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation, its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S, the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. [The UniProt Consortium]
Keywords: | Anti-UPF1, Anti-hUpf1, Anti-NORF1, Anti-KIAA0221, EC=3.6.4.-, Anti-ATP-dependent helicase RENT1, Anti-Nonsense mRNA reducing factor 1, Anti-Up-frameshift suppressor 1 homolog, Anti-Regulator of nonsense transcripts 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-038A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Goat |
Species reactivity: | human, mouse (Expected: rat, zebrafish, X. laevis, X. tropicalis, chicken, turkey, bovine, dog, horse, guinea pig_10141, pig, panda, orangutan, rhesus monkey, gorilla, west indian ocean coelacanth, medaka fish, spotted green pufferfish) |
Immunogen: | synthetic peptide. The epitope recognized by A300-038A-T maps to a region between residue 1075 and the C-terminus (residue 1118) of human Regulator of Nonsense Transcripts 1 (up-frameshift mutation 1 homolog) using the numbering given in entry NP_002902.2 (GeneID 5976). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K14326 | Matching products |
UniProt ID : | Q92900 | Matching products |
Gene ID | GeneID 5976 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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