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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F40140-0.05ML | 50 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F40140-0.2ML | 200 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS pH 7.4 with 0.09% sodium azide. PKM2 is a glycolytic enzyme that catalyzes the transfer... more
Product information "Anti-Pyruvate Kinase / PKM2"
In 1X PBS pH 7.4 with 0.09% sodium azide. PKM2 is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt] Protein function: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723). In addition to its role in glycolysis, also regulates transcription (PubMed:18191611, PubMed:21620138). Stimulates POU5F1-mediated transcriptional activation (PubMed:18191611). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages. Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs. Plays a general role in caspase independent cell death of tumor cells (PubMed:17308100). [The UniProt Consortium]
Keywords: | Anti-PKM, Anti-p58, Anti-OIP3, Anti-OIP-3, Anti-CTHBP, Anti-THBP1, Anti-Tumor M2-PK, Anti-Pyruvate kinase PKM, Anti-Pyruvate kinase 2/3, Anti-Opa-interacting protein 3, Anti-Pyruvate kinase muscle isozyme, Anti-Thyroid hormone-binding protein 1, Pyruvate |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F40140 |
Properties
Application: | WB, IF, IHC, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, primate, rat |
Immunogen: | Portion of amino acids 476-505 from the human protein |
Format: | Purified |
Database Information
KEGG ID : | K00873 | Matching products |
UniProt ID : | P14618 | Matching products |
Gene ID | GeneID 5315 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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