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Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Protein function: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. [The UniProt Consortium]
Keywords:
Anti-PTX3, Anti-TSG-14, Anti-TNFAIP5, Anti-TNF alpha-induced protein 5, Anti-Pentaxin-related protein PTX3, Anti-Pentraxin-related protein PTX3, Anti-Tumor necrosis factor alpha-induced protein 5, Anti-Tumor necrosis factor-inducible gene 14 protein, PTX3
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